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Exposure to phthalates during pregnancy can affect a newborn’s brain development, study finds
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Phthalates — the synthetic chemicals used in everyday products for food packaging, personal care, toys and more — have been linked to abnormal neurological development in infants.

Now, scientists may have discovered a biological pathway for how this phenomenon could occur. Researchers found that in utero exposure to phthalates is linked with altered metabolism of neurotransmitters and amino acids involved in brain maturation, according to a study published Wednesday in the journal Nature Communications.

The report is the first to use untargeted metabolomics — the study of all small molecules or metabolites in a biological system — to connect a mother’s phthalate exposure to a newborn’s metabolites, and those metabolites to neurological development, said senior study author Dr. Donghai Liang via email.
“This represents an important step forward in understanding how prenatal chemical exposures shape infant development at the molecular level,” added Liang, an associate professor of environmental health at Emory University’s Rollins School of Public Health in Atlanta.

First introduced in the 1920s, phthalates are used to make plastics softer and more flexible, primarily in polyvinyl chloride (PVC) products such as vinyl flooring, medical devices, children’s toys, food packaging or shower curtains. The chemicals also help lubricate substances and carry fragrances in various personal care products including deodorant; nail polish; perfumes; hair gels, sprays or shampoos; soaps; and body lotions.

Phthalates are also endocrine disruptors that have been linked to preterm birth, infant genital abnormalities, childhood obesity, asthma, cancer, cardiovascular issues, and low sperm count and testosterone in men.

“We conducted this study because phthalates are everywhere in our daily lives,” Liang said, hence their nickname “everywhere chemicals.”

Harming infant health
The findings are based on mother-newborn pairs enrolled in the Atlanta African American Maternal-Child Cohort between 2016 and 2018. In urine samples collected from 216 mothers between eight weeks and 14 weeks of gestation at visit one and 145 participants between 24 and 30 weeks’ gestation at visit two, the authors measured eight phthalate metabolites. Participants were around age 24 on average, and their levels of some phthalate metabolites were higher than the average determined by the National Health and Nutrition Examination Survey.

Within a day or two of birth, the authors collected the babies’ blood via a heel stick.

The team found prenatal phthalate levels were associated with lower levels of tyrosine, an amino acid and precursor to the thyroid hormone thyroxine. Thyroxine was also abnormally low in those with in utero phthalate exposure, and low thyroxine has been previously associated with greater vulnerability to illness and neurodevelopmental issues in newborns, the authors said. Tyrosine is also a precursor to the neurotransmitters dopamine, norepinephrine and epinephrine, all of which partly contribute to the body’s fight-or-flight response. Low levels of these neurotransmitters can lead to various problems, including anxiety, depression and trouble focusing.

Prenatal phthalate exposure was also linked with lower levels of the essential amino acid tryptophan, which converts into 5-hydroxytryptophan (or 5-HTP), which then turns into serotonin. Both 5-HTP and serotonin were also low. Serotonin has several critical roles in the body, including mood regulation, sleep, learning, memory, digestion and the body’s response to stress. Previous research has linked low serotonin with mood disorders such as depression and anxiety, sleep problems, and digestive issues.

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Narwhals may be using their tusks to play, new study finds
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Scientists say they have the first recorded video evidence of narwhals using tusks not only to strike and manipulate fish during feeding but also engage in what appears to be playful behavior, according to the latest research.

The narwhal, often referred to as the “unicorn of the sea” in a nod to its trademark tusk, has long remained an enigma. Scientists have observed few interactions of narwhals in their natural habitat, creating speculation about the purpose of the species’ distinctive spiraling tusk.
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Found predominantly in males, the tusk grows up to 10 feet (3 meters) long — and previous research has suggested it serves as a competitive display to secure mates. But now, with the help of drones, research conducted in the Canadian High Arctic has uncovered that a narwhal may use its tusk for more than just courtship.

In total, the researchers newly identified and described 17 distinct behaviors of narwhals involving prey. The findings revealed a wide range of interactions and dynamics between narwhals and fish as well as the extraordinary agility, precision and speed of their tusks to track moving targets, according to the study published February 27 in the journal Frontiers in Marine Science.

“Seeing that these animals are not actually hunting the fish but exploring, manipulating and interacting with it was really a game changer,” said lead author Dr. Gregory O’Corry-Crowe, a research professor in the Harbor Branch Oceanographic Institute at Florida Atlantic University.

Since so little is understood about this whale species, researchers like O’Corry-Crowe and his colleagues are working diligently to conduct studies to document narwhals’ unknown behaviors to better understand how these animals adapt in a rapidly shifting habitat as oceans warm and sea ice melts.
Narwhal exploratory behavior
The study team captured the groundbreaking footage using drones in Creswell Bay, on the eastern side of Somerset Island in Canada’s Nunavut territory, during the summer of 2022.

As the researchers analyzed the footage, they noticed subtle nuances in the narwhals’ behavior. Footage even captured one instance of a narwhal interacting with a fish by repeatedly nudging it with its tusk — which is actually a giant tooth — without attempting to eat it.

When researchers observed a lack of aggression in some interactions between narwhals and fish, they realized these scenarios were more similar to a cat-and-mouse game, in which the animals were chasing or “playing” rather than hunting, O’Corry-Crowe said.

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02 Apr 2025 - 02:16 pm

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